Ribozyme self-replication?
نویسندگان
چکیده
منابع مشابه
A self-replicating ligase ribozyme.
A self-replicating molecule directs the covalent assembly of component molecules to form a product that is of identical composition to the parent. When the newly formed product also is able to direct the assembly of product molecules, the self-replicating system can be termed autocatalytic. A self-replicating system was developed based on a ribozyme that catalyzes the assembly of additional cop...
متن کاملLigand requirements for glmS ribozyme self-cleavage.
Natural RNA catalysts (ribozymes) perform essential reactions in biological RNA processing and protein synthesis, whereby catalysis is intrinsic to RNA structure alone or in combination with metal ion cofactors. The recently discovered glmS ribozyme is unique in that it functions as a glucosamine-6-phosphate (GlcN6P)-dependent catalyst believed to enable "riboswitch" regulation of amino-sugar b...
متن کاملAn autocatalytic network for ribozyme self-construction.
1. Dietrich, L.E., Teal, T.K., Price-Whelan, A. & Newman, D.K. Science 321, 1203–1206 (2008). 2. Pomposiello, P.J. & Demple, B. Adv. Microb. Physiol. 46, 319–341 (2002). 3. Pollack, M. in Principles and Practice of Infectious Diseases (eds. Mandell, G. L., Bennett, J. E. & Dolin, R.) 2310–2335 (Churchill Livingstone, New York, 2000). 4. Pomposiello, P.J., Bennik, M.H. & Demple, B. J. Bacteriol....
متن کاملSelf-replication
What is it? Self-replication is a means by which an individual can duplicate itself. Such molecular photocopying occurs when a reaction product directs its own formation from component parts. This has been hypothesized to be a route by which primitive life may have sustained itself. How does it work? It involves product-directed assembly of components to form a new product. The simplest self-re...
متن کاملExceptionally fast self-cleavage by a Neurospora Varkud satellite ribozyme.
Most of the small ribozymes, including those that have been investigated as potential therapeutic agents, appear to be rather poor catalysts. These RNAs use an internal phosphoester transfer mechanism to catalyze site-specific RNA cleavage with apparent cleavage rate constants typically <2 min(-1). We have identified variants of one of these, the Neurospora Varkud satellite ribozyme, that self-...
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ژورنال
عنوان ژورنال: Nature
سال: 1989
ISSN: 0028-0836,1476-4687
DOI: 10.1038/339507a0